30 November 2016

Notes - thinking internally / settling in



       Late morning. You are at Pine Hill Lakes Park, facing east by the earth dam while Carol takes her walk this rather brisk partly cloudy day. Jill is house cleaning while you’re out. – Amorella

       1120 hours. It is a rather quiet morning; however, as we drove in we saw Tim K. taking one of his “Words in the Wild” (juniors and seniors) classes up along the larger lake. He gets paid for doing what he loves. You can’t beat that.

       You think that since nothing worthwhile is going on in your head, that is, nothing entertaining; you might as well work continue working on that first chapter. – Amorella

       1125 hours. That’s rather blunt, Amorella, but I cannot deny the thought.

       This, that I can read your thoughts, does not appear to bother you. – Amorella

       1128 hours. I have learned to accept myself, thoughts and all, as I am. It is somewhat disconcerting (the bluntness) sometimes, but what you come up with is true enough. I just haven’t expressed openly in words.

       So, exactly how are your thoughts expressed when and/or before they are not in words? – Amorella

       1132 hours. This is a good question. This particular one above on nothing entertaining was certainly not based on emotion as I appeared to be somewhat bored at the time. I must have been at least semi-conscious of the thought. I don’t know if semi-conscious is the same as being a part of the subconscious or not. I always need to define things before I tackle them.

       This appears to be the case most of the time. A read through the blog will show this to be true. – Amorella

       1138 hours. This blog is more than seven years old. I can hardly believe it.

       You don’t need to believe it; you can’t ‘believe’ it because it is a true statement. – Amorella

       1150 hours. I found “Internal Monologue” on Wikipedia. I could not find semi-consciousness.

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Internal monologue, also known as inner voice, internal speech, or verbal stream of consciousness is thinking in words. It also refers to the semi-constant internal monologue some people have with themselves at a conscious or semi-conscious level (see Default mode network). Much of what people consciously report "thinking about" may be thought of as an internal monologue, a conversation with oneself. Some of this can be considered as speech rehearsal.

  • When reading, some people's internal monologue moves their muscles slightly as if they were speaking; this is called subvocalization.
  • In some medical or mental conditions, there is uncertainty about the source of internal sentences. Attribution for an internal monologue may lead to concerns over schizophrenia, hallucinations, or hearing voices. This internal monologue is stimulated by the sensory parts of the brain, activating both auditory and visual receptors.
  • Contemplation "attempts to calm the internal voice" by various means.
  • In the philosophical field of languate there is much research about internal speech in correlation with the building and usage of phrases in one's own idiom and thus the importance of language in the process of thinking.
In neuroscience, the default mode network (DMN), (also default network, or default state network), is a network of interacting brain regions known to have activity highly correlated with each other and distinct from other networks in the brain.

The default mode network is most commonly shown to be active when a person is not focused on the outside world and the brain is at wakeful rest, such as during daydreaming and mind-wandering. But it is also active when the individual is thinking about others, thinking about themselves, remembering the past, and planning for the future. The network activates "by default" when a person is not involved in a task. Though the DMN was originally noticed to be deactivated in certain goal-oriented tasks and is sometimes referred to as the task-negative network, it can be active in other goal-oriented tasks such as social working memory or autobiographical tasks. The DMN has been shown to be negatively correlated with other networks in the brain such as attention networks. Thinking about others also could include guessing their thoughts, emotions, and psychological motivations.

Evidence has pointed to disruptions in the DMN with people with Alzheimer’s and autism spectrum disorder.

Function

The default mode network is known to be involved in many seemingly different functions:

Information regarding the self
  • Autobiographical information: Memories of collection of events and facts about one’s self
  • Self-reference: Referring to traits and descriptions of one’s self
  • Emotion of one’s self: Reflecting about one’s own emotional state
Thinking about others:
  • Theory of Mind: Thinking about the thoughts of others and what they might or might not know
  • Emotions of other: Understanding the emotions of other people and empathizing with their feelings
  • Moral reasoning: Determining just and unjust result of an action
  •  
  • Social evaluations: Good-bad attitude judgments about social concepts
  • Social categories: Reflecting on important social characteristics and status of a group
Remembering the past and thinking about the future:
  • Remembering the past: Recalling events that happened in the past
  • Imagining the future: Envisioning events that might happen in the future
  • Episodic memory: Detailed memory related to specific events in time
  • Story comprehension: Understanding and remembering a narrative

The default mode network is active during passive rest and mind-wandering. Mind-wandering usually involves thinking about others, thinking about one’s self, remembering the past, and envisioning the future. Electrocorticography studies (which involve placing electrodes on the surface of epileptic patient’s brains) have shown the default mode network becomes activated within an order of a fraction of a second after participants finish a task.

Studies have shown that when people watch a movie, listen to a story, or read a story, their DMNs are highly correlated with each other. DMNs are not correlated if the stories are scrambled or are in a language the person does not understand, suggesting that the network is highly involved in the comprehension and the subsequent memory formation of that story. The DMN is shown to even be correlated if the same story is presented to different people in different languages, further suggesting the DMN is truly involved in the comprehension aspect of the story and not the auditory or language aspect.

The default mode network has shown to deactivate during external goal-oriented tasks such as visual attention or cognitive working memory tasks, thus leading some researchers to label the network as the task-negative network. However, when the tasks are external goal-oriented tasks that are known to be a role of the DMN, such as social working memory or an autobiographical task, the DMN is positively activated with the task and correlates with other networks such as the network involved in executive function.

Anatomy

Graphs of the dynamic development of correlations between brain networks. (A) In children the regions are largely local and are organized by their physical location; the frontal regions are highlighted in light blue. (B) In adults the networks become highly correlated despite their physical distance; the default network is highlighted in light red.

The default mode network is an interconnected and anatomically defined set of brain regions. The network can be separated into hubs and subsections:

Functional hubs: Information regarding the self

1  Posterior cingulate cortex (PCC) & precuneus: Combines bottom-up (not controlled) attention with information from memory and perception. The ventral (lower) part of PCC activates in all tasks which involve the DMN including those related to the self, related to others, remembering the past, thinking about future, and processing concepts plus spatial navigation. The dorsal (upper) part of PCC involves involuntary awareness and arousal. The precuneus is involved in visual, sensorimotor, and attentional information.
2  Medial prefrontal cortex (mPFC): Decisions about self-processing such as personal information, autobiographical memories, future goals and events, and decision making regarding those personally very close such as family. The ventral (lower) part is involved in positive emotional information and internally valued reward.
3  Angular gyrus Connects perception, attention, spatial cognition, and action and helps with parts of recall of episodic memories

Dorsal medial subsystem: Thinking about others

   Functional hubs: PCC, mPFC, and angular gyrus
   Dorsal medial prefrontal cortex (dmPFC): Involved in social directed thought such as determining or inferring the purpose of others' actions
   Temporoparietal junction (TPJ): Reflects on beliefs about others, also known as theory of mind
   Lateral temporal cortex: Retrieval of social semantic and conceptual knowledge
   Anterior temporal pole: Abstract conceptual information particularly social in nature
    
Medial temporal subsystem: Autobiographical memory and future simulations

   Functional hubs: PCC, mPFC, and angular gyrus
   Hippocampus (HF+): Formation of new memories as well as remembering the past and imagining the future
   Parahippocampus  (PHC): Spatial and scene recognition and simulation
   Retrosplenial cortex (RSC): Spatial navigation
   Posterior inferior parietal lobe (pIPL): Junction of auditory, visual, and somatosensory information and attention
    
The default mode network is most commonly defined with resting state data by putting a seed in the posterior cingulate cortex and examining which other brain areas most correlate with this area. The DMN can also be defined by the areas deactivated during external directed tasks compared to rest.

It has been shown that the default mode network exhibits the highest overlap in its structural and functional connectivity, which suggests that the structural architecture of the brain may be built in such a way that this particular network is activated by default. In the infant brain, there is limited evidence of the default network, but default network connectivity is more consistent in children aged 9–12 years, suggesting that the default network undergoes developmental change.

Function connectivity analysis in monkeys shows a similar network of regions to the default mode network seen in humans. The PCC is also a key hub in monkeys; however, the mPFC is smaller and less well connected to other brain regions, largely because human’s mPFC is much larger and well developed.

Diffusion MRI imaging shows white matter tracks connecting different areas of the DMN together. The structural connections found from diffusion MRI imaging and the functional correlations from resting state fMRI r show the highest level of overlap and agreement within the DMN areas. This provides evidence that neurons in the DMN regions are linked to each other through large tracks of axons and this causes activity in these areas to be correlated with one another.

Pathophysiology

The default mode network has been hypothesized to be relevant to disorders including Alzheimer’s disease, autism, schizophrenia, depression, chronic pain and others.

People with Alzheimer’s disease show a reduction in glucose (energy use) within the areas of the default mode network. These reductions start off as slight decreases in mild patients and continue to large reductions in severe patients. Surprisingly, disruptions in the DMN begin even before individuals show signs of Alzheimer’s disease. Plots of amyloid-beta, which is thought to cause Alzheimer’s disease, show the buildup of the protein is within the DMN. This prompted Randy Buckner and colleagues to propose the high metabolic rate from continuous activation of DMN causes more amyloid-beta protein to accumulate in these DMN areas. These amyloid-beta proteins disrupt the DMN and because the DMN is heavily involved in memory formation and retrieval, this disruption leads to the symptoms of Alzheimer’s disease.

DMN is thought to be disrupted in individuals with autism spectrum disorder. These individual are impaired in social interaction and communication which are tasks central to this network. Studies have shown worse connections between areas of the DMN in individuals with autism, especially between the mPFC (involved in thinking about the self and others) and the PCC (the central core of the DMN). The more severe the autism, the less connected these areas are to each other. It is not clear if this is a cause or a result of autism.

Lower connectivity was found across the default network in people who have experienced long term trauma, such as childhood abuse. Among people experiencing posttraumatic stress disorder, lower activation was found in the posterior cingulate gyrus compared to controls. Hyperconnectivity of the default network has been linked to rumination in depression and chronic pain.

Modulation

The default mode network (DMN) may be modulated by the following interventions and processes:
   Acupuncture – Deactivation of the limbic brain areas and the DMN. It has been suggested that this is due to the pain response.
    
   Meditation – Structural changes in areas of the DMN such as the temporoparietal junction, posterior cingulate cortex, and precuneus have been found in meditation practitioners. There is reduced activation and reduced functional connectivity of the DMN in long-term practitioners. Various forms of nondirective meditation, including Transcendental Meditation and Acem Meditation have been found to activate the DMN.
    
   Sleeping and resting wakefulness
    
                        Resting wakefulness – Functional connectivity between nodes of the DMN is strong.
                        Onset of sleep – Decrease in connectivity between the DMN and the task-positive network.  
                        Stage N2 of NREM sleep – Decrease in connectivity between the posterior cingulate cortex and medial prefrontal cortex.
                        Stage N3 of NREM sleep – Further decrease in connectivity between the PCC and MPFC.
                        REM sleep – Possible increase in connectivity between nodes of the DMN.
   Sleep deprivation – Functional connectivity between nodes of the DMN in their resting-state is usually strong, but sleep deprivation results in a decrease in connectivity within the DMN. Recent studies suggest a decrease in connectivity between the DMN and the task-positive network as a result of sleep loss.
    
   Psychedelic drugs – Reduced blood flow to the PCC and mPFC was observed under the administration of psilocybin. These two areas are considered to be the main nodes of the DMN. One study on the effects of LSD demonstrated that the drug desynchronizes brain activity within the DMN; the activity of the brain regions that constitute the DMN becomes less correlated.
    
History

Hans Berger, the inventor of the electroencephalogram, was the first to propose the idea that the brain is constantly busy. In a series of papers published in 1929 he showed that the electrical oscillations detected by his device do not cease even when the subject is at rest. However, his ideas were not taken seriously, and a general perception formed among neurologists that only when a focused activity is performed does the brain (or a part of the brain) become active. In the 1950s, to the surprise of the researchers, Louis Sokoloff and his colleagues noticed metabolism in the brain stayed the same when a person went from a resting state to performing effortful math problems suggesting active metabolism in the brain must also be happening during rest. In the 1970s, Ingvar and colleagues observed blood flow in the front part of the brain became the highest when a person is at rest. Around the same time, intrinsic oscillatory behavior in vertebrate neurons was observed in cerebellar Purkinje cells, inferior olivary nucleus and thalamus.

In the 1990s, with the advent of positron emission tomography (PET) scans, researchers began to notice that when a person is involved in perception, language, and attention tasks the same brain areas become less active compared to passive rest, and labeled these areas as becoming “deactivated”. Later, experiments by neurologist Marcus E. Raicle’s lab at Washington University School of Medicine and other groups showed that the brain's energy consumption is increased by less than 5% of its baseline energy consumption while performing a focused mental task. These experiments showed that the brain is constantly active with a high level of activity even when the person is not engaged in focused mental work. Research thereafter focused on finding the regions responsible for this constant background activity level.

Raichle coined the term "default mode" in 2001 to describe resting state brain function; the concept rapidly became a central theme in neuroscience. Around this time the idea was implanted that this network of brain areas is involved in internally directed thoughts and is suspended during specific goal-directed behaviors. In 2003, Greicius and colleagues examined resting state fMRI scans and looked at how correlated different sections in the brain are to each other and found the correlation maps showed the same areas Raichle found active during rest and that others found to deactivated. It was important because it demonstrated a convergence of methods all lead to the same areas being involved in the DMN. Since then other resting state networks (RSNs) have been found, such as visual, auditory, and attention networks, some of them are often anti-correlated with the default mode network.

The number of publication per year with "default mode network" or "default network" in the title. Searches were done in Google Scholar.

In the beginning to mid 2000s, researches labeled the default mode network as the task negative network because it was deactivated when participants had to perform tasks. DMN was thought to only be active during passive rest and then turned off during externally focused goal-directed tasks. However, studies have demonstrated the DMN to be active in external goal-directed tasks which is known to involve the DMN such as social working memory or autobiographical tasks.

Around 2007, the number of papers referencing the default mode network have skyrocketed. All years prior to 2007, there were 12 papers published that referenced “default mode network” or “default network” in the title, however, between 2007 and 2014 there were 1384 papers published. One reason for the increase in papers is a result of the robust effect of finding the DMN with resting state scans. Another reason is the DMN can be measured with a short and effortless resting state scans meaning they can be performed on any population including young children, clinical populations, and nonhuman primates. A third reason is role of the DMN has been expanded to more than just a passive brain network.

Criticism

Some have argued the brain areas in the default mode network only show up together because of the vascular coupling of large arteries and veins in the brain near these areas, not because these areas are actually functionally connected to each other. Support for this argument comes from studies that show changing in breathing alters oxygen levels in the blood which in turn affects DMN the most. These studies however do not explain why the DMN can also be identified using PET scans by measuring glucose metabolism which is independent of vascular coupling or in electrocorticography studies measuring electrical activity on the surface the brain.

The idea of a "default network" is not universally accepted. In 2007 the concept of the default mode was criticized as not being useful for understanding brain function, on the grounds that a simpler hypothesis is that a resting brain actually does more processing than a brain doing certain "demanding" tasks, and that there is no special significance to the intrinsic activity of the resting brain.

From Wikipedia – default mode network
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       Afternoon. You had lunch at Potbelly’s after reading at the cemetery, then you stopped at Kroger’s. Jill had left by the time you arrived home. – Amorella

       1447 hours. I have been reading some research on language and thinking and it appears to, that following my earlier observations above the Wiki quotes – I was thinking without language. The research argues on whether language influences thought more or whether thought influences language more. This is a copy of what I wrote earlier:

**
       So, exactly how are your thoughts expressed when and/or before they are not in words? – Amorella

       1132 hours. This is a good question. This particular one above on nothing entertaining was certainly not based on emotion as I appeared to be somewhat bored at the time. I must have been at least semi-conscious of the thought. I don’t know if semi-conscious is the same as being a part of the subconscious or not. I always need to define things before I tackle them. 

(copied from above before the Wikipedia)

**
       1459 hours. It appears that the thought was on my mind but language didn’t display itself until you made your observation. Is it possible that somewhere in the unconscious mind thought exists without the verbal language to express it? Presently and intuitively I say, Yes, it is possible that the unconscious mind thinks without verbal language needed to  express it. Actually, it’s a given. Lower animals ‘think through problems’ without the verbal language. Problem solving can be demonstrated by body language and then resolved, for example.  

       You are feeling rather inadequate here because after thinking the problem out you see a simple solution for yourself. Time for a break. – Post. - Amorella

       Carol forgot yogurt so you have returned to Kroger. Such is life, eh, boy? – Amorella

       1618 hours. When retired and time is more readily available such little problems are easily resolved without emotions playing much of a part. You forget something (we all forget), you back and get it or wait until tomorrow. Letters appearing on the screen is a calming effect – I am conscious and alive enough to put my fingers to the keyboard when appropriate. It is still interesting to wonder how it is that unconscious thought can be transposed without consciousness not picking it up? Non-religious people could pray every day without knowing it. This is strikingly funny.

       Later. Dusk. You are home. This is the reason, you see, that in the books, the Dead spend ‘time’ having to think things out. Socrates was talking about the Living when he said, “Know Thyself” but in here, it works for the Dead too. Psychologists talk about how people suppress things and that some of this comes out in symbolic form through dreams and nightmares. Symbolic form because words are not needed to communicate between the so called consciousness and unconsciousness. In here when you are physically dead unconsciousness and consciousness are one in the same – the personality and the heartansoulanmind of the individual is one and the same. This takes some getting used to, but then ‘the truth’ is like that, it takes a while, so to speak, to get used to. What do you think? – Amorella

       1712 hours. You sound reasonable, in fact, you haven’t really varied from this concept. Is this a theme in Soki’s Choice?

       Yes. It is strange that you wouldn’t trust yourself enough to just accept these revolving themes. – Amorella

       1722 hours. I take nothing for granted, Amorella. This comes from my believing you were God when we first met. I was on a walk in the neighborhood, long ago, in the early eighties. It was dark and I was on another street heading back to 800 Majken Place where we lived. A voice said, “Who are you?” to me and I replied to myself half-heartedly, “And who are you?” You know, I don’t think you actually replied, but I got goosebumps and assumed you were God. However, I immediately and ever after had my doubts. If you had responded, “I am God,” I would have been confused, at least momentarily, about who the pronoun was referring to and I would have immediately questioned my sanity because I would have known it wasn’t me. Basic orndorff momentary confusion. (1734)

       This is an example of learning what you may have known but then you didn’t know how to listen. – Amorella

       1736 hours. I need to stop and let this settle in.

       Post. - Amorella






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